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Physiologically based pharmacokinetic modelling of semaglutide in children and adolescents with healthy and obese body weights
Just as the younger age and lower comorbidity burden likely explain the more pronounced reduction in all-cause mortality observed among younger individuals, these same factors may also account for their significantly lower risk of the composite outcomecomprising acute and chronic pancreatitiscompared with older participants, who instead exhibited an increased risk
Conclusion There was no apparent effect of renal impairment or haemodialysis on the pharmacokinetics of oral semaglutide
640 In the DPN study, tanezumab provided effective pain reduction in DPN, with no safety concerns observed
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