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However, it's not impossible to use a larger needle like this

A patient who loses 15% of body weight on tirzepatide over the next 18 months will enter a retatrutide program, if they choose to transition, from a metabolically stronger position than one who waited

NICE approved semaglutide (Wegovy) for weight management in specialist NHS weight management services in 2023 (TA875), but availability is limited to patients with: BMI 35 kg/m with at least one weight-related comorbidity, or BMI 30 kg/m with exceptional circumstances Lower BMI thresholds apply for people from some minority ethnic groups (typically 27.5 kg/m) Participation in a specialist weight management programme Treatment limited to a maximum of 2 years Access varies by region due to local integrated care board (ICB) implementation decisions and limited NHS specialist service capacity

Using the same dosing schedule, patients can receive treatment up to twice if their symptoms return (63)

The right choice depends on your individual cause of deficiency, your symptoms, and how quickly you need results