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Average Weight Loss in the Orforglipron phase 3 ATTAIN-1 Trial Across the 72-week study period, participants: Lost up to 15% of their body weight at the highest dose At 36 mg: 54.6% lost 10%, 36.0% lost 15%, 18.4% lost 20% body weight (all higher than placebo)

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Dehydration may cause brain fog, impaired cognitive function, fatigue, and muscle response issues

Effect of intensive diet and exercise on self-efficacy in overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial