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It mimics naturally occurring hormones, GLP-1 and GIP, which help regulate appetite and insulin levels
11 12 GLP-1s lower blood sugar, blood pressure, body weight, and inflammationall of which reduce strain on the heart and blood vessels 13 GLP-1 receptors are found in the heart and arteries, where they may also improve endothelial function, increase nitric oxide, and reduce oxidative stress, helping stabilize plaque and improve how the heart uses energy, especially during stress
GLP-1 drugs are one part of a healthy lifestyle, not a quick fix for weight loss
A representative Phase 2 escalation schedule looked like this: Lower dose arms were reached with correspondingly fewer steps
The MHRA advises that GLP-1 medicines should only be used for authorised medical purposes and obtained through legitimate prescribing and pharmacy services
