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Providers weigh measurable criteria, such as BMI, alongside lifestyle factors, such as how someone has responded to diet and exercise in the past, before recommending a treatment plan

Retatrutide additionally agonizes the GIP receptor and the glucagon receptor, making it a triple agonist with distinct effects on energy expenditure and adipose tissue beyond what GLP-1 agonism alone produces

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doi:10.3945/ajcn.2010.29885