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Here, we show that in mouse islets, tirzepatide stimulates insulin secretion predominantly through the GLP-1R, owing to reduced potency at the mouse GIPR

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These factors highlight the need for careful consideration and monitoring when prescribing these medications, especially in individuals at risk of eating disorders (Bartel et al., 2024)

The idea is simple: if topical use can improve surface-level markers, deeper systemic exposure may be worth exploring for people who want support that goes beyond what a serum can do on its own

This dose is for treatment initiation and is not effective for glycemic control