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Cifuentes, M
The 15 mg dose reached 11.2 kg at the same time point
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Besides the effects of GLP-1RAs on macrophage polarization into the M2 phenotype and on foam cell formation, GLP-1RAs may act directly on endothelial cells and limit endothelial dysfunction, which is primarily characterized by a reduction in nitric oxide (NO) bioavailability [46, 47]
This suggests that the co-treatment with ferrous iron again switched the signaling mechanisms and mode of cell death from mitochondrial dysfunction-dependent necrosis after APAP alone to LPO-dominated ferroptosis after APAP + Fe 2+ (Figure 1)
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