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Following those promising results, a phase 1 study tested ascending doses (3, 9, 20, 40, 80, and 150 g) of SAR441255 against placebo reported a decrease in both fasting and post prandial blood glucose in the SAR441255 group

The key takeaway: most patients tolerate these medications well, especially when doses are titrated slowly over months

and external audits ensure that outcomes remain fair and statistically aligned with published return-to-player figures

Smith et al