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Large clinical trials, including those supporting FDA approval of semaglutide, show that gastrointestinal and appetite-related side effects are almost entirely reversible within weeks to months of stopping treatment

Weight Management Support May help support steady progress toward long-term weight management goals for appropriate patients

However, these observational studies have inherent limitations, including potential residual confounding (as some registries lack complete data on important cancer risk factors like smoking), selection bias, and the challenge of detecting rare events

O'Donnell, J

References Bremer, J