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In further experiments, four insomniac patients adapted in the laboratory for 1 night, with placebo injections for 2 nights, were treated continuously for 4 days with DSIP administered 1 hour before bedtime

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Research indicates that specific bacterial populations are altered in these patients, which may contribute to their psychiatric symptoms (184, 185)

Some obesity-medicine experts have called the drug a "game changer." Research has found it can lead to a 15% to 20% reduction in body weight over 68 weeks when paired with a reduced-calorie diet and regular exercise

doi: 10.1016/j.diabres.2019.05.001 51 PerkovicV.De ZeeuwD.MahaffeyK