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The glucagon receptor is activated by glucagon a hormone that raises blood sugar and, critically, increases energy expenditure by promoting fat burning from adipose tissue

doi: 10.1080/15548627.2020.1822089 23 BounousG.GervaisF.AmerV.BatistG.GoldP

Semaglutide has the advantage of already being FDA-approved for chronic weight management (under the brand name Wegovy) for individuals with a BMI 30 or BMI 27 with at least one weight-related condition

The 2-year STEP 5 trial found strong tolerability