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The downregulation of ChaC1, along with other genes, appears to contribute to the mechanisms by which lung adenocarcinoma cells develop resistance to cisplatin, highlighting the UCA1-TXNIP axis as a potential therapeutic target for overcoming drug resistance (Zhou et al., 2020)
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362 NAD + deficiency correlates with disturbed circadian clocks during aging Besides mitigating the oxidative damage, NAD + can extend lifespan by driving the circadian rhythms
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