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Reduction of cysteine sulfinic acid in peroxiredoxin by sulfiredoxin proceeds directly through a sulfinic phosphoryl ester intermediate

doi: 10.1002/ijc.11387 211 HuangBWarnerMGustafssonJA

Increased Energy Levels: May contribute to higher energy and reduced fatigue

Goal: Selectively clear senescent cells by disrupting the nuclear FOXO4p53 interaction so freed p53 triggers apoptosis demonstrated in preclinical (mouse) work only, not established in humans [1] [2] Schedule: Daily subcutaneous injections across a 16-week course with gradual dose escalation