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Notoriously, hyperhomocysteinemia-induced brain injury and disruption of BBB are mediated by the release of pro-inflammatory cytokine and immunomodulatory dysfunction to protect the injured brain (Zhang et al
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To determine whether Trim37 -deletion-induced PGC depletion is germ cell autonomous, we first constructed a Trim37 knockout embryonic stem cell line ( Trim37 -del) based on an E14-derived ESC line in which 3Flag was knocked in at the C-terminus of Trim37 ( Trim37-3 Flag ) (Supplementary information, Fig
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