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Kennedy C, Hayes P, Salama S, Hennessy M, Fogacci F

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Why Joint Aches Occur with B12 Supplementation When joint discomfort does arise in temporal association with vitamin B12 therapy, several possible explanations may be considered, though none represent a direct toxic or pharmacological effect of cobalamin itself

however, it is unclear whether intracellular GSH production by tumours themselves is required

The maximum dose is 15 mg weekly, typically achieved after 21 weeks of treatment if the Mounjaro dosage schedule is followed correctly