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After first puncture, use the vial within 28 days
24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases
Studies suggest that up to 20-30% of patients may experience some degree of diarrhea during treatment
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