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In a typical encapsulation experiment, PLGA nanoparticles exhibited a hydrodynamic diameter of 170 30 nm (z-average, PDI = 0.162) as measured using dynamic light scattering with anionic effective surface charge (20.5 5.3 mV) due to the terminal carboxylate groups on the PLGA polymers

Collectively, these findings suggest that tirzepatide may affect OSAS severity predominantly through metabolic and inflammatory improvement, with potential adjunctive neuromuscular contributions

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It is also published in the Journal of Medical Toxicology , the official journal of the American College of Medical Toxicology.