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Approximately equal numbers of patients were randomized to receive initial therapy with placebo, 100 mg of Januvia once daily, 500 mg or 1000 mg of metformin twice daily, or 50 mg of sitagliptin twice daily in combination with 500 mg or 1000 mg of metformin twice daily

371,372 These findings are consistent with earlier studies indicating that uncontrolled large-volume fluid resuscitation markedly increases the risk of mechanical ventilation, abdominal compartment syndrome, and mortality