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The research literature describes suppression of pro-inflammatory pathways and support of antioxidant defense systems, contributing to its characterization as a broadly cytoprotective copper peptide 1

Both medications require gradual dose titration to mitigate gastrointestinal (GI) symptoms and improve adherence

Bowel changes become more predictable : Constipation is common, especially if fiber and fluids are low

During follow-up, 12 patients in the oral semaglutide (10.4%) and 11 patients in the subcutaneous semaglutide (6.2%%) group discontinued treatment due to side effects, without significant differences between the two formulations ( p = 0.27) (Supplementry Figure S2o)

It activates two incretin receptors: GIP and GLP-1