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APAP overdose leads to excessive generation of the highly reactive metabolite n-acetyl-p-benzoquinone imine (NAPQI), which depletes glutathione (GSH), increases oxidative stress, and causes mitochondrial dysfunction, finally triggering immune response-mediated hepatotoxicity and massive hepatocytes necrosis [15, 16]
10.12048/j.issn.1674-229X.2024.10.001 136 ZhangC.LiJ.WangL.MaJ.LiX.WuY.et al (2024)
Read the full Zinc monograph Herb & supplement monograph Vitamin B6 Interacts with 210 drugs Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells
However, everyone reacts differently to supplemental medication, and it may not be safe for every person
