SAM acts as a methyl donor, assisting in the synthesis of phosphatidylethanolamine and phosphatidylcholine
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Conversely, a few studies reported high levels of vitamin B12 in the blood of patients with a worse COVID-19 outcome 48,49 potentially due to cytolysis leading to the release of intracellular B12 into the plasma and disrupted B12 clearance by the liver, which is often affected in these patients 50