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Both sRAGE forms are believed to be competitive inhibitors of RAGE

In particular, unlike the conventional method, the method of the present invention can achieve preparation of (R)-4-chloro-3-hydroxy butyric acid alkyl ester having an optical purity of more than 99%ee from the hydrolysis of the racemic 4-chloro-3-hydroxy butyric acid alkyl ester using the enzyme

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