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GI adverse events occur in 50 to 60 percent of patients at higher doses, making careful titration essential
Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123
Second, a large percentage of patients had multiple reasons for discontinuation in their notes
It is the oxidizing action of such acids that potentially result in skin irritation reactions once they reach the viable skin layers 3
The most common include redness, swelling, or soreness at the injection site
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