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BPC-157 and GLP-1 medications act through entirely different receptor systems and metabolic routes

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Published Online First: 13 January 2022

According to our current understanding of GLP-1RAs mitochondrial regulatory effect and oxidative stress suppression ability on eye diseases, the molecular pathways mainly involve the PINK1/Parkin-mediated mitophagy pathway and the GLP-1R-ERK1/2-HDAC6 signaling pathway (see Figure 3)