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People with severe deficiencies often need higher and more frequent doses initially, regardless of the delivery method
Isoprenaline increased cAMP levels, activated PKA, inhibited PP1, and increased the phosphorylation state of phospholamban (Neumann et al
With combined activation (CagriSema) the effect does not add linearly, but supra-additively , which is why the combination has a stronger clinical result than either component alone
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