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doi: 10.3390/microorganisms8020269 555 CrookNFerreiroAGasparriniAJPeseskyMWGibsonMKWangBet al

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Wegovy is a glucagon-like peptide (GLP-1) receptor agonist, which is injected once per week and indicated as an adjunct to a reduced-calorie diet and increased physical activity for weight management, including weight loss and weight maintenance

Tirzepatide vs Semaglutide : Final Verdict for 2026 By the clinical numbers, tirzepatide wins producing roughly 47% more average weight loss than semaglutide in the first-ever direct head-to-head comparison

There is also a class-related warning about thyroid tumors (common to all GLP-1s) based on animal studies, though no such cases were reported in retatrutide trials so far